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KMID : 0370220140580030151
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Yakhak Hoeji
2014 Volume.58 No. 3 p.151 ~ p.157
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A Flow Cytometrical Analysis of the Antitumor and Immunostimulatory Effects of LCT-CT, a Cold-water Extract Prepared from Rice Grasshopper Oxya japonica japonica Thunberg
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Chung Kyeong-Soo
Kim Bit-Na
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Abstract
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Water extracts of rice grasshopper (Oxya japonica japonica Thurnberg) were prepared and their antitumor and immunostimulatory activities were investigated using a flow cytometer. When LCT-CT was ip injected into ICR mice at the dose of 33.3 mg/kg before and after the implantation of 4×105 cells/mouse of sarcoma 180 tumor cells, it inhibited the growth of the tumor cells by 96.6%, showed lymphoblstogenic activities on the splenic lymphocytes and increased the expression of CD25 molecules on the splenic T lymphocytes. When co-cultured with the splenic lymphocytes of a BALB/
c mouse, LCT-CT showed strong immunostimulatory activities at the concentration of 25~100 μg/ml by significantly
increasing lymphoblasts ratio and CD25 expression.
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KEYWORD
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rice grasshopper, Oxya japonica japonica, antitumor, sarcoma 180, CD25, flow cytometer, lymphoblast, immunostimulation
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